The BaSICS (Baby Skin Integrity Comparison Survey) study: A prospective experimental study using maternal observations to report the effect of baby wipes on the incidence of irritant diaper dermatitis in infants, from birth to eight weeks of age

BackgroundBaby wipes have been shown to be safe and effective in maintaining skin integrity when compared the use of water alone. However, no previous study has different formulations wipe. The aim BaSICS was identify any differences incidence irritant diaper dermatitis (IDD) infants assigned three brands wipe, all marketed as suitable for neonates, but which contained varying numbers ingredients.MethodsWomen were recruited during prenatal period. Participants randomly receive one wipe first eight weeks following childbirth. All participants received same nappies. reported their infant's on a scale 1–5 daily using bespoke smartphone application. Analysis effect brand clinically significant IDD (score 3 or more) conducted negative binomial generalised linear model, controlling possible confounders at baseline. Analysts blind wipe.ResultsOf 737 women enrolled, 15 excluded (admitted neonatal intensive care, premature other infant health issues). Of 722 eligible babies, 698 (97%) remained full 8-week duration, 24.6% whom had some point study. Mothers with fewest ingredients fewer days nappy rash (score≥3) than two (p = 0.002 p < 0.001). Severe (grades 4 5) rare (2.4%).ConclusionsRarity severe suggested that sensitive formula baby are used cleansing babies from birth changes. significantly IDD. Daily observations recorded application proved highly acceptable method obtaining real-time data IDD.Clinical Trial registrationThis not designed registered clinical trial intervention normal patterns care took place. who already decided disposable nappies product agreed observe report infants’ condition; return they 9-week supply free wipes. Baby ingredients. Women (2.4%). Rarity